Not everyone tolerates them equally. Treatments have included exercise, horse riding, tobacco, opium, and fasting. What about the horses used to make pregnant mares urine based drugs? Ginseng may come to the rescue on this front, possibly supporting healthy sleep cycles by aiding relaxation. Origins: One of the inevitable aspects of the aging process in women is the decreased . 2,654. The theory behind reflexology is that these areas correspond to organs and systems of the body. Additionally, a simple search for vaginal dryness on Amazon.com will give you an idea of just how many and what kinds of OTC products are available. What should I do if I have a reaction to Metformin? The premise is that serotonin levels rise which can alter the temperature set point in the hypothalamus. There have been numerous reports in the medical literature and general media as to the effectiveness of various over-the-counter agents and prescription drugs in reducing menopausal hot flash symptoms. SSRIs are called selective because they seem to primarily affect serotonin, not other neurotransmitters. Therefore, for the time being, assume that they carry the same risks are oral medications. Nutrition: It should go without saying, avoid refined and processed foods, choose more whole foods, fresh fruit, vegetables and complex carbohydrates. The dosage and duration of these medications most appropriate in alleviating hot flashes is unknown; however, regimens using low to moderate dosages seem to be as effective as those using high dosages and have significantly fewer reported adverse effects. Covaryx, Essian, Estratest, Menogen, Syntest D.S., Syntest H.S. Newsletter. . Which explains why China was so gung ho to have EU stop accepting US horsemeat back in 2013? As much as it may seem that these hormones are safer than the Premarin family of drugs, there is no solid evidence to prove this. Data suggest that genistein might have a potential preventative role in reducing coronary artery disease. It is believed to help influence prostaglandin synthesis and help moderate menopausal symptoms. It has a long history of being used for blood pressure control, but it has potentially annoying side effects, such as dry mouth, constipation, drowsiness, or difficulty sleeping. However there have been no long-term studies like the WHI performed to assess their safety profile. Answer: You should not take Metformin if you are breastfeeding. I'm also not too happy to find out they put horse urine in them! Summary: Creatinine urine increased is found among people who take Metformin, especially for people who are male, 50-59 old, have been taking the drug for 10+ years. @dorisena I would love to be able to get up only 3 times a night! The lack of distinction between FDA-approved bioidentical hormones (often referred to as synthetics) and compounded bioidentical hormones has resulted in considerable misunderstanding regarding exactly what BHRT is. Firstly, it reduces the amount of sugar produced by cells in the liver. Some clinical studies suggest that replacing dietary fats with flaxseed might be effective for patients with milder symptoms. Exercise: Exercise is vital to keeping symptoms in check. Why? In some instances, consumption of vitamin B-6 can give your urine an unusual odor. 2023. Metformin is one of the most widely-used medications for type 2 diabetes and has been prescribed to more than 120 million people worldwide. Answer: Metformin works by decreasing the amount of sugar that the liver produces and the intestines absorb. Metformin is used to treat high blood sugar levels that are caused by a type of diabetes mellitus or sugar diabetes called type 2 diabetes. Seehttp://www.health.harvard.edu/newsletters/Harvard_Womens_Health_Watch/2011/September/bioidentical-hormones-help-or-hype. In a similar fashion to SSRIs, SNRIs (serotonin and noepinephrine reuptake inhibitors) block the reabsorption (reuptake) of the neurotransmitters serotonin and norepinephrine in the brain. Heat can cause the patch to release the estrogen too quickly so it is important not to expose them to high heat or direct sunlight (e.g. Those mares are registered Quarter Horses bred to registered Quarter Horse stallions with the exception being some foals are bred to be Warmbloods. Several clinical studies have shown that acupuncture can reduce symptoms of menopause. The vast majority of advocates of BHRT are referring to the compounded versions where hormones are custom-mixed by a pharmacist unapproved drugs. 1. Thank you. Where is metformin found naturally The Diabetes Drug Developed From French . cough or hoarseness. Why do pharmaceutical giant Pfizer persist with the Premarin line of drugs? Vasomotor symptoms (i.e. In fact one large study found that people taking metformin had a lower risk of developing cancer than those not taking the medication. But there are alternatives. Over-the-counter estrogen and progesterone creams typically contain bio-identical, or plant- or herbal-based hormones. There is also convincing evidence that some prescription drugs which are not licensed for treating menopausal symptoms do in fact alleviate hot flashes and night sweats. In a letter published in the Annals of Internal Medicine, physicians from . Why does everything from receding hairline to erectile dysfunction to menopause have to be drugged out of us? Stress Management: It is a well-known fact that stress induces more severe hot flashes. It has been found that melatonin and some of its analogs promote sleep. Aging and menopause are normal reactions to growing older. Your guess is as good as mine. Reflexology is generally relaxing and may be an effective way to alleviate stress. Therefore, for the time being, assume that they carry the same risks are oral medications. Using metformin alone, with a type of oral . Of note is that Paroxetine/Paxil is sold under the trade name of Brisdelle for the treatment of menopausal hot flashes the first non-hormonal treatment to be approved by the FDA for hot flashes associated with menopause. A small randomized study of women aged 45-60 experiencing vasomotor symptoms who were administered either reflexology or non-specific foot massage showed there was a reduction in both groups but no significance between the two groups. However, it is important to take the correct dosage if too high, there may be adverse side effects (e.g. Lactic acidosis is a serious and potentially fatal condition. So no metformin is not made from horse urine. Take Action to Help End the Misery of PMU Horses. allow estrogen receptor binding), have less CAD (coronary artery disease) and breast and uterine cancer and fewer vasomotor symptoms compared with those who consume Western diets. diarrhea. SSRIs are called selective because they seem to primarily affect serotonin, not other neurotransmitters. Prempro, Premphase). And, as always, please consult with your doctor before you use these or any other alternatives for the relief of menopausal symptoms. Estrogen, when used with a progestin, can increase the risk of heart disease (such as heart attacks), stroke, serious blood clots in the lungs/legs, dementia, and cancer of the breast/ovaries. There are, however, safety concerns which should preclude its use. These are powerful drugs yet in severe cases some doctors may be willing to prescribe one of these treatments with the patients consent. And as you can see, there are so many alternatives for the treatment of menopausal symptoms that do not contain CEEs (conjugated equine estrogens) made with the urine from pregnant mares. It is created by eHealthMe based on reports of 395,495 people who have side effects when taking . Penicillin is often used for skin . Is the captive bolt a humane death for horses? (LogOut/ Red Clover belongs to the coumestin group. A potential confounder in most hot flash trials is the placebo response rate, which in many studies has been reported as between 18 and 40 percent. It is also used to prevent the development of type 2 diabetes in people at high risk for the disease and to treat metabolic syndrome. Random testing has shown that the indicated potency of compounded hormones varies substantially. Others say flaxseed does not significantly affect menopause-specific quality of life or hot flash symptoms. This is similar to rates found in studies of hormonal agents, but makes it more difficult to ascertain the true effects of therapy on hot flashes. The exact mechanism of action for many of the non-prescription alternatives is unknown, however several theories have suggested they act as antagonists on estrogen receptors, or alternatively as selective estrogen receptor modifiers (SERMs). Several placebo-controlled studies that evaluated the effectiveness of red clover in reducing hot flashes showed a modest reduction in frequency in women administered various amounts of red clover compared to those receiving placebo. Over-the-counter (OTC) products for vaginal dryness can be used intermittently as needed, in-between or in addition to prescription estrogens. 2 However, a larger field study in the UK found significant improvement in insulin resistance in 18 chronically laminitic horses and ponies studied on the drug for as long as 220 days. These come in a variety of forms, namely; pill, patch, injection, gels, cream (vaginal and skin), vaginal insert, transdermal skin spray, vaginal ring, and vaginal tablet. Accordingly dosage may be inappropriate for treating symptoms. I have seen first hand the decr if carefully restricting diet and increasing exercise - even in horses not overweight. Some examples that fall into each of these categories are listed. Pros: Convenient. Read More. Of note is that Paroxetine/Paxil is sold under the trade name of Brisdelle for the treatment of menopausal hot flashes the first non-hormonal treatment to be approved by the FDA for hot flashes associated with menopause. There are two classifications of bioidentical hormones; (1) FDA-approved and; (2) compounded in pharmacies based on hormone levels measured in saliva and blood tests (not FDA approved). SSRIs block the reabsorption (reuptake) of serotonin in the brain, making more serotonin available. As part of The Horse Funds continuing campaign against the manufacture and use of the Premarin family of drugs Premarin, Prempro and Duavee we have compiled a list of alternatives to drugs made with pregnant mares urine (conjugated equine estrogens). Dong Quai finds its roots in traditional Chinese medicine. general feeling of discomfort. It is derived from the French lilac plant and has been used to treat diabetes for centuries. Please browse the websites above to learn more about these products and consult your doctor to determine whether any would be beneficial in treating your symptoms. hot flashes, night sweats, palpitations) are typically experienced due to reduced estrogen levels and cause sleep disturbances. Red clover belongs to the coumestin group. Updated on March, 2018 Jane Allin BY JANE ALLIN. Others are thought to relieve stress and anxiety to help with menopausal mood swings, or have mild anti-inflammatory action. To date there are mixed reviews on its effectiveness for some it works, for others it doesnt. Moreover, the benefits are unsurpassed: maintenance of muscle and joint strength, increased metabolism, reduced weight, improved cardiovascular health, increased cognitive function, maintenance of bone integrity, and the list goes on. Genistein, an isoflavone found in low concentrations in soybeans and elevated amounts in certain soy-derived food has attracted scientific interest for its possible benefits in cancer and heart disease prevention as well as reducing menopausal symptoms. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); Enter your email address to follow this blog and receive notifications of new posts by email. Change), You are commenting using your Facebook account. Results: In this study, we demonstrated that metformin increased urinary sodium excretion by reducing phosphorylation of the thiazide-sensitive Na-Cl cotransporter (NCC) in acute and chronic metformin administration. There have been cases of endometrial (uterine) cancer noted among some users of bioidenticals. Over-the-counter (OTC) products for vaginal dryness can be used intermittently as needed, in-between or in addition to prescription estrogens. Objective: To determine pharmacokinetics and oral bioavailability of metformin in healthy horses. This includes both FDA-approved and compounded hormones. Melatonin serum levels also decrease. Some clinical studies suggest that replacing dietary fats with flaxseed might be effective for patients with milder symptoms. If so, ask your physician about alternatives. lower back or side pain. The most common side effects of gabapentin are drowsiness, dizziness, and a spacey feeling. We did not compile this list, and we will check with the ones who put it together. This was included to warn the reader of the dangers associated with this particular natural alternative. Claiming to have a double-blind, placebo-controlled clinical study to back its effectiveness, it contains 100% natural ingredients, all on the FDAs approved Generally Recognized As Safe (GRAS) list. Moreover, because it contains coumarins, interactions with warfarin and photosensitization have been reported. It is also used in the treatment of polycystic ovary syndrome. Clonadine acts in the brain to decrease blood pressure. Unlike oral forms, estrogen by-passes the liver and goes directly into the bloodstream so they are safer for individuals with liver problems. Pros: As with skin patches, safer for people with liver problems as they are directly absorbed through the skin into the bloodstream. Metformin hydrochloride is a type of antidiabetic medicine known as a biguanide. Avoid high fat dairy products and meats and supplement these items with healthy fats such as olive oil, nuts, seeds and lean cuts of meat or fish. In menopausal women hormones levels are particularly unstable without a normal concentration. Fill in your details below or click an icon to log in: You are commenting using your WordPress.com account. First hand the decr if carefully restricting diet and increasing exercise - even in horses not overweight fall each! Than those not taking the medication with flaxseed might be effective for patients with milder symptoms lilac and... Are particularly unstable without a normal concentration take Action to help with mood! Your urine an unusual odor particularly unstable without a normal concentration too happy to find out they put horse in. By cells in the brain, making more serotonin available medicine, physicians from horse urine an icon log. 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