You can choose the number of channels of the device (4 or 8), each channel range from -800 mbar to 7 bar, and you even have the possibility to integrate a pressure or vacuum source inside the instrument. 6). Improved reliability and reproducibility of results are possible due to the pulseless flow. 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, LineUp Series, the new generation of microfluidic controllers, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, Dry, oil-free gas, air, any non corrosive or non explosive gas, Aqueous solvent, oil, organic solent, biological sample, Control in real-time, protocol automation, data record and export. Weighing in less than 170 g and with a volume of 140 cm3, Excellent stability and response time thanks to Fluigent pressure and liquid handling expertise. The pressure automatically adjusts in the background to maintain the set flow rate. Inject and switch different flow paths. Control without a PC using the Flow EZ hardware interface with one hand. 
If you are seeking to replace high-precision syringe pumps or other conventional instruments, we offer modern microfluidic systems and components that enhance productivity.. Our LineUp product range is the next generation of microfluidic systems. Flow-rates can be monitored or controlled using Fluigent DFC self-learning flow rate control algorithm. When combined with theLINKmodule, thePush-Pullcapabilities are extended by using Fluigent software to control the system, or to generate time based protocols and reccord data(OxyGEN software). Configuration 2: 2 pressure modules 2 flow sensors. Whether your application is with droplets, cell biology, particle studies, or in other research areas, we have the expertise and knowledge to provide the most cost-effective and technically advanced solutions for your fluid control needs. Our engineered systems tackle these limitations by bringing a cost-effective solution with a highly reduced footprint. The technology used in this pressure pumpavoids cross-contaminationbecause liquids only contact air. Combine as many modules as you want to fit your application needs. TheLineUpPush-Pullis a standalone controller with the ability to deliverfinely regulated pressureor avacuumthrough a single outlet over the range of-800 to +1000 mbar. For more information or a technical discussion, 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics. Custom software application: Public SDK libraries are available on GitHub for all integration into the users proprietary software, Adapted to cell culture or other experiments involving resistance variations: the algorithm adjusts its model to the setup resistance in real-time, Save precious sample or reagent: reduced time to reach desired flow rates uses less liquid during a calibration step, Save time with reduced settling time and no calibration. In this stand-alone configuration, the device allows for pressure or flow rate control and volume dispense making it ideal for benchtop use. Single gateway for industrial-grade microfluidic control: The platform can be used to control a pressure source and power other third-party devices required in the microfluidic system. The benefits of this technology are listed below. We offer modern microfluidic systems and components that enhance productivity. The flow generated can be measured or controlled with FLOW UNITs and the Flowboard. Janire, S., Raquel, C.-C., R_oisn, M. O. Expand your system up to 32 outlets with 4 modules. The applied pressure will automatically adjust to maintain the flow rate. The use of pressure to handle fluids also provides a quick response time allowing for precise operations such as stop flow and accurate pressure/flow rate steps. 3 pressure modules consisting of two 0 2000 mbar and a -800 + 1000 mbar are connected to the main F-OEM board for pressurizing two fluidic reservoirs, allowing for pressure-based fluid handling.
Based on our industry leading experience, Fluigent has developed the patented QuadCore pneumatic system, the most advanced microfluidic pumping technology available. The technology consists of a uniquely engineered assembly of electronics, sensors integrated with a micropump, and pneumatics to provide high performance. It provides a dual interface USB and RS232 for high versatility in the integration. Fluigent has developed (patent pending) an all-in-one, free standing, compact, integrated pressure-based control with an internal pressure supply technology. It is at the heart of the Fluigents next generation performance providing the fastest, most stable and compact system for microfluidics available. Its improved reactivity allows countering, in real-time, the interactions between microfluidic channels in complex situations. Get full control of the setup in a single interface with plug and play capabilities available for all desktop OS, that allows control, monitoring, and automation feature. The technology used in this pressure pumpavoids cross contaminationbecause liquids only contact air. Use the P-SWITCH buttons to quickly commute outlets between the two supplied pressure(s)/vacuum(s) and focus on the experiment. Fluigents i (patent pending) powerful pressure regulation algorithm is based on physical equations and self-learning routines that offer several benefits: By directly connecting a flow rate sensor, it is possible to monitor or control flow rate in real time. The MFCS system can provide negative or positive pressures as needed by using up to four or eight independently controllable channels. Emerging point of care applications make use of more complex fluidic operations and require compact systems. Front. Combined with Flow EZ and Push-Pull, set a versatile system for pressure-base microfluidic experiments. The FASTAB microfluidic patented technology used by MFCS series avoids cross contamination as there is no direct contact between the instrument and the reagents. Reach your pressure targets rapidly and get your experiment started instantaneously. Conventional water monitoring is based on laboratory instruments that are generally sophisticated and expensive. Fluigents broad range of solutions for use in microfluidic and nanofluidic applications offer greater control, automation, precision, and ease of use. No flow sensors. The addition of aFLOW UNITenables one tocontrol or monitor flow rateas well asmeasure a dispensed volume. Fluigent has delivered thousands of patented pressure-flow controllers systems to hundreds of customers worldwide. Connecting the pressure outputs to airtight reservoirs provides precise and smooth control of the sample flow into the microfluidic device. The MFCSTM series and Flow EZTM with Fluigent valves can be used for automated cell perfusion as in the next video. The MFCS can be controlled by Fluigent software to automate your protocols. It is well established that pressure-based flow control offers unequaled flow stability and response times. It provides flexibility without compromising performance (accuracy and response time). The MFCS series products are well adapted to the manipulation of fluid volumes in the low to sub microliter per minute range. This technology can be integrated in any custom project. Most pressure controllers require a pressure source which is regulated. In the base configuration, the system controls pressure or vacuum, and the liquid flow is a function of system resistance, fluid viscosity, etc. Plug directly the sensor to the PC and benefit from a compact solution for pressure detection. Fluigent was the first company to introduce pressure-based flow control to handle fluids in microfluidics. 6). The MFCS series product range is the first generation of microfluidic systems. By using the FASTAB microfluidic patented technology, the MFCS generates a constant pressure-driven flow rate that allows for reliable and repeatable experiments. What I like most is that you are independent of a computer and can directly control both positive and negative pressure.. It allows optimal flow control with the reliability required for demanding industrial environments. The technology is powered by an embedded rechargeable battery to facilitate portability. We have a large range of flow sensors ranging from 0-1.5 L/min to 0-5 mL/min. 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, Control in real-time, protocol automation, data record and export. To ensure excellent response time while guaranteeing the best performance, Fluigent developed a technology that makes use of proportional valves. The pulseless and precise control enabled by our pressure-driven technology is critical for repeatable results in many applications. ThePXmodules, are available in different pressure and vacuum ranges, to provide the optimum level of pressure control and resolution. It is a standalone, modular platform that will perform complex fluidic operations.
TheFlow EZ supports reservoir sizes from 2 mL to one liter laboratory bottles. When combined with theLINKmodule, the Flow EZcapabilities are extended by using Fluigent software to control the system, or to generate time based protocols and reccord data(OxyGEN software). 4 slots for pressure or switch modules. For flow-rate monitoring and control. Based on our industry leading experience, Fluigent has developed the patented QuadCore pneumatic system, the most advanced microfluidic pumping technology available. Connect the outlets of the P-SWITCH to independent reservoirs to perform independent injections. is well-suited technology for applications that require mobile or compact fluidic control devices, including point of care (PoC) diagnostic and testing, or for water and soil on-site analysis. Along with the MCFS-EZ or MCFS-EX, a Manifold can be added to redirect the pressure to multiple fluid reservoirs. Liquid flow rate ranges from a few nL/min to 5 mL/min. Support reservoir sizes from 2 mL to one liter laboratory bottles. Instead of looking at the PC, users can keep their eyes on the microscope, adjusting the control dial with one hand. It is at the heart of the Fluigents next generation performance providing the fastest, most stable and compact system for microfluidics available. The Flow EZmodules, are available in different pressure and vacuum ranges, to provide the optimum level of pressure control and resolution.
Combine up to 12 modules as your work flow grows. In addition, a microfluidic pressure pump can easily be integrated into a setup with the Software Development Kit (SDK). Benefit from the best performance and Fluigent expertise for your project. The sensor can be directly connected to a PC via USB, and display measurement in real time onthe Fluigent OxyGENsoftware interface. Fig 2: (left) Pneumatic schematic of a standard fluidic system using pressure to move fluids (right) Pneumatic schematic of Fluigent new technology. Each module is a separate and independent pressure channel. One can use large reservoirs and maintain continuous, pulseless flow for days without refilling. The pressure automatically adjusts in the background to maintain the set flow rate. Our technology is an excellent fit for such applications as it is fully connected and provides excellent fluidic performance while being compact. Flow sensors are connected for flow rate monitoring and control. 2. Improved reliability and reproducibility of of results is possible due to the pulseless flow. The use of pressure allows for a quick response time as well. The MFCS-EX provides up to 8 negative or positive pressure channels to pressurize multiple fluid reservoirs. It provides the best response time, pulseless, and highly stable flow conditions for high precision industrial microfluidic applications. The pressure controllers immediately provide the requested pressures with very high stability thanks to the feedback loop. Two pressure modules consisting of a 0 2000 mbar and -800 + 1000 mbar are connected to the main F-OEM board for pressurizing two fluidic reservoirs, allowing for pressure-based fluid handling. Configuration 3: 3 pressure modules 1 switch module. The PX Pressure-driven flow control simplifies fluid management even for multiple fluids, and reduces the time needed to add or remove channels. The Flow EZ integrates the all-new DFC (Direct Flow Control) algorithm. Each module consists of a separate pressure channel and can be controlled independently. The PRESSURE UNIT product line allow for the accurate measurement of pressure and vaccum within the range -1000 mbar to 7 bar. The FLUIGENT PX pressure controller is a single, miniaturized electronic pressure controller with an integrated and intelligent feedback loop for highest performance. With the use of pressure instead of mechanical action, the Flow EZTMgets a responsiveness ten times faster than syringe pumps. Combined with a FLOW UNIT it allows for direct control of flow rate. Migrating cells in dynamic chemical gradients generated by a microfluidic chamber (cells, gray; chemoattractant with fluorescein,green). As an alternative, microfluidic-based portable devices have been developed for on-site analysis. The device is well designed and allows for easy control of my microfluidic chips. The F-OEM makes use of Fluigents patented Fastab 2 technology. Valve and switch platform for directing the fluid flow, including bidirectional and rotary multi-port port valves. No switch modules. Control without a PC using the Push-Pull hardware interface with one hand. Select modules you need and combine them together. Although an external pressure supply allows working over large pressure ranges (generally up to 7 bar) and high gas flow rates, it can be cumbersome, and integration into a device is challenging. & Lourdes, Basabe-Desmonts Fernando, B.-L. Microfluidics and materials for smart water monitoring: A review.
It can support a wide range of connections (Wi-Fi, BLE, IoT, USB, industrial bus), and embedded protocols. TheLineUpP-SWITCHis a pneumatic valve controller. For more information or a technical discussion, 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, Explore our 15 years of field-proven experience, Developing a new fluidic system? These can easily be combined tomatch all application requirementsor reconfigure the system for a new experimental design. Mixed pressure ranges can be connected to the same board (positive and negative pressures, and Push-Pull). In this stand-alone configuration, the device allows for pressure or flow rate control and volume dispense making it ideal for benchtop use.
How to set the Flow EZ (power and pressure supply), Fluidic and pneumatic connection to the microfluidic setup, Extend the pressure system by adding modules, How to send and apply an order to pressurize a reservoir, How to disconnect a module to modify the pressure system, Add a flow sensor to control directly in flow rate, Switch the module OFF and stop the experiment, 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, LineUp Series, the new generation of microfluidic controllers, Comparison between peristaltic, syringe and pressure pumps for microfluidic applications, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, 0,1% on the measured value (effective beyond 10% of the maximum pressure), Dry, oil-free gas, air, any non corrosive or non explosive gas, Aqueous solvent, oil, organic solent, biological sample, Control in real-time, protocol automation, data record and export. It can have an integrated pressure/vacuum source or be coupled with the FLPG+, an external pressure source, for those who dont have access to a laboratory bench mounted gas source. Point of Care (PoC) testing allows one to diagnose diseases at or near the patient site.
Pulse-free flow is critical for generating high quality and repeatable results. All-in-one pressure controller and supply powered by battery or line voltage. For point-of-care applications, a touch screen can be developed based on your needs. Our innovative pressure-based microfluidic controllers are compatible with lab on a chip device and a wide variety of microfluidic technologies that will allow you to focus on the science, not on the setup. By providing two pressure sources (any vacuum or pressurefrom -800 to +2000 mbar), each module is able to deliver one of the two provided pressures through8 independent outlets. Instead of looking at the PC, users can keep their eyes on the microscope, adjusting the control dial with one hand. However, adding such leakage components influence the overall performance: the maximum pressure that can be reached has now decreased of about 15% (from 375 mbar to 310 mbar illustrated in the graph Fig. The algorithm includes a continuous optimization of the parameters that allow it to adapt to the interactions between microfluidic channels in complex situations. Fluigents unique broad range of solutions for use in microfluidic and nanofluidics applications ensure full control of flow rates with a greater control, automation, precision, ease of use and also minimize contamination.
Point of care devices needing a small footprint can have engineering challenges. Fluigent has developed a pressure-based technology that offers an integrated pressure supply and control (positive and negative pressure) in a light (< 170 g) and compact format (L*l*H = 7*5*4). Sachdeva, S., Davis, R. W. & Saha, A. K. Microfluidic Point-of-Care Testing: Commercial Landscape and Future Directions. Either 4 or 8 channels are available with different pressure ranges for microfluidic experiments. Due to its individually stackable channels adapted for different pressures, the PX series allowed for control of the different pressure variations required. This allows to perform operations that require fast response time, or require fast change between applied positive pressure and vacuum. Graphically monitor in real-time the pressure measurement using the OxyGEN software. Fluigent was the first company to solve this problem by introducing an innovative technology: pressure pumps. The delivered software package is suitable for Windows and Linux platforms. Pulse-free flow is critical for generating high quality and repeatable results. Integrated flow control: To switch from pressure control to flow rate control, one can directly add a flow sensor from our industrial FS series to the F-OEM without the need of an additional board. This allows the user to set a flow rate directly on the instrument display. When using a gas micropump alone, pressure drops are very slow, as shown in Fig. This allows the user to set a flow rate directly on the instrument display. Instead of looking at the PC, users can keep their eyes on the microscope, adjusting the control dial with one hand. Each module is a separate and independant pressure channel. The field-proven technology ensures to obtain quickly reliable and superior results for your experiments. The F-OEM makes use of the best combination of pneumatic, mechanical, and electrical elements associated with our new generation algorithm: Fluigent Direct Flow-rate Control (DFC) a self-learning algorithm that performs continuous adjustment over the algorithm parameters based on the actual response time. Combine up to 12 modules as your work flow grows. These often require more bulky equipment as the internal technology is more advanced. Continuous monitoring of water resources such as freshwater, seawater, and, in particular, wastewater and drinking water, for human and animal consumption, is essential2.
For more information or a technical discussion, 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics. ThePRESSURE UNITis a stand-alone sensor forcontinuous measurementof the pressure in a fluidic path. With the Fluigent Microfluidic Flow Control System (MFCS-4C) one can sort cells by size, shape and deformability as shown in this publication in the journal Lab-on-a-Chip and explained in the next video. As the equipment is not easily portable, samples can be compromised during travel. Fluigent developed the patented FASTAB technology: a pressure-driven technology that has no moving parts and includes an advanced feedback control algorithm to maintain precise pressure control. The MFCS is a pressure based microfluidic flow controller. It has been designed to maximize versatility with its dual interface USB and RS232 ports and is delivered with a full software package (SDK) to ease integration into Windows or Linux-based software platforms. A photonic technology institute tests a variety of lab-on-chip systems, the number of flow channels and the required pressures vary from one test to another.
The applied pressure will automatically adjust to maintain the flow rate. Customize your own controller to answer your control needs. The PX module is a CE and RoHS compliant single controller available in 3 pressure ranges. Excellent response time, pulseless and highly stable, Configurable with pressure and switch control modules, Standalone platform adapted to industrial uses. The Adapt is used to connect Flow EZ modules with different pressure ranges without the need of additional pressure sources. The Flow EZ range of modules allow for regulatation of pressure / vacuum down to -800 mbar and up to 7 bar. 5 that compares Fluigent solution with a standalone gas micropump. The use of pressure to handle fluids also provides a quick response time allowing for precise operations such as stop flow and accurate pressure/flow rate steps. Pressure modules (positive pressure, negative pressure, or push-pull modules), microfluidic valve modules, and flow sensors are directly connected to the main platform. Biotechnol. The microfluidic laboratories and industry were struggling to perform their research and develop equipment to the level and precision required in terms of fluid control. See an example of applications using the MFCS series: Separation of parasites from human blood using deterministic lateral displacement, S. H. Holm, J. P. Beech, M. P. Barrett and J. O. Tegenfeldt, Lab Chip, vol.11, 2011. Using this engineered solution, pressure drop takes less than a second, and the maximum pressure reachable has not deteriorated (see graph). Video courtesy of Pr Satoshi Sawai ( University of Tokyo, Japan). With the addition of a pressure leakage component, the pressure drop now takes about 5 seconds (see Fig. The platform allows one to choose the number of pressure modules (with different ranges, if required), valve modules, and flow sensors. ThePush-Pullmodules, are available in different pressure and vacuum ranges, to provide the optimum level of pressure control and resolution. Pressurize up to 32 reservoirs simultaneously or independently. 1186, (2021). When connected to a computer, one can use our Fluigent software tobenefit from automationorlive monitoring and recording of data. Fluigent pressure and flow controllers bring this performance and benefits to the system. 0.1% thanks to our field-proven, patented FASTAB technology allowing optimal flow control with the robustness required in demanding industrial environments. Configure your own system: The F-OEM consists of a main board to which one can add pressure and switch control modules depending on the configuration required. In fact, it is possible to observe that the micropump will take more than a minute to reach zero pressure. In this stand-alone configuration, the device allows for pressure or flow rate control and volume dispense making it ideal for benchtop use. Extension slots available, Pressure: 25 mbar (0.36 psi) / 69 mbar (0.9 psi) / 345 mbar (5 psi) / 1000 mbar (14.5 psi) /, USB cable, domino, electrical wires, 4 mm and 6 mm pneumatic tubing (4 m), Power supply 108 W if using a Switch module, Positive pressure source with necessary tubing and fittings, Negative pressure source with necessary tubing and fittings, Pressure regulator if pressure of different ranges are used. Based on the patented FASTABTM technology, our pressure and flow controllers ensure a stable and pulseless flow to enhance accuracy and reproducibility in the experiments. Support reservoir sizes from 2 mL to one liter laboratory bottles. The P-SWITCH allows to multiply the outlets of the system and the SWITCH EZ controls microfluidic valves.
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