Give them the contact details for your cancer doctor so they can ask for advice. But it has subsided. This is to check that your blood cells are at a safe level to have chemotherapy. You may find it hard to fasten buttons or do other fiddly tasks. Drink plenty of fluids and eat as much fresh fruit and vegetables as you can. A number of large-scale clinical trials have demonstrated that using a combination of oxaliplatin and fluoropyrimidines as an adjuvant chemotherapy for stage II/III colon cancer improved the prognosis. They can give you advice and may give you creams or medicines to help. But some can be permanent. They can give you painkillers to help. You may have nosebleeds or bleeding gums after brushing your teeth. So you may start treatment with a lower amount (dose) of the drug or have a different treatment. Less commonly you might get pain from other areas of the body such as your joints, bones, limbs, or chest. The second year my mum had the same combination they had to reduce her dose for other reasons but the upside was a significant reduction in her side effects with only a minimal reduction in strength . Never worry about being over cautious and always mention anything that seems out of the ordinary - I mentioned in passing that my tongue felt funny and like Id eaten a whole bag of aniseed balls and the oncologist stopped the oxaliplatin from then on. Save these numbers in your phone or keep them somewhere safe. Oxaliplatin is a third-generation platinum compound in which the platinum atom is complexed with a 1.2 diamino-cyclohexane and with an oxalate ligand as a leaving group. CAPOX (also called XELOX) - capecitabine and oxaliplatin; capecitabine alone; Stage 4 or recurrent . Your cancer doctor or GP can tell you more about live and inactivated vaccinations. Instructions on how you can make a PDF version of this page using the print function on your browser. Physicians . The week I was on chemo was the time when I dropped a bit of weight, was fortunate not nauseous, but not hungry. Accessing the HOPE course through Macmillan Wellsprings story. It takes weeks for it to show up and once it's warm out I don't think it would be nearly so bad. Taste changesusually get better after treatment finishes. Search our clinical trials database for all cancer trials and studies recruiting in the UK, Questions about cancer? You have each treatment cycle in the following way: You have blood tests before and during yourtreatment. You may have tests to check your lungs. Can't change anything now. Distant metastasis has been the main failure pattern for locoregionally advanced rectal cancer (LARC) patients, and intensified neoadjuvant chemotherapy has become a popular research topic. But for some people they may never go away. During treatment you usually see a cancer doctor, a chemotherapy nurse or a specialist nurse, and a specialist pharmacist. You may also feel unwell with flu-like symptoms such as a high temperature and joint pain. If I'm tired I take a nap, but I try to be as active as I can. 11-13 Oxaliplatin has been studied in combination with gemcitabine (GemOx) in 2 large randomized trials and, although neither demonstrated a statistically significant survival advantage . I wish you luck as you start your chemo jouney. Contact your advice line if you have diarrhoea, such as if you've had 4 or more loose watery poos (stools) in 24 hours. A company limited by guarantee, registered in England and Wales company number 2400969. If your immune system is weak, you need to avoid live vaccinations. The skin may also begin to peel. Keep to your regular schedule and let your doctor or nurse know. I guess that makes me T3 N1b M0. I was also lucky with good blood work. For instance, some people might notice their poo is quite dark or they might pass fresh blood. We haven't listed all the side effects here. If you are sick just after taking the tablets, contact the hospital. Hi, been a few years since I've been on here, I had bowel cancer in Aug 2009, since then I've had secondary cancer in various places, at the moment I'm stage 4 and have small tumours in my throat,lung and left shoulder, told it's slow growing, this is the second time I've hadOxaliplatin but having capecitabine tablets for 2 weeks as well, I'm on my 2nd session of 4 and am having constanttinnitus, has anyone else suffered with this as I'm thinking of cutting out the Oxaliplatin for the last 2 sessions to save my hearing or am I being over causious, many thanks. Any changes to your skin are usually temporary and improve when treatment finishes. Our community is available 24/7 and has dedicated forums where you can get advice and ask our experts. Isle of Man company number 4694F. Live vaccines contain a very weak version of the illness they are vaccinating you against. Skinproblemsincludea skin rash which might be red and itchy. This means you have the drugs and then a rest to allow your body to recover. . In the UK, live vaccines includerubella, mumps, measles, BCG, yellow fever and one of the shingles vaccines called Zostavax. I don't know if you'll be able to find them now that winter is over. This completes your first cycle of XELOX. drinking plenty of fluids, especially water. If your immune system is severely weakened, you should avoid contact with children who have had the flu vaccine as a nasal spray as this is a live vaccine. Call your doctor or the 24-hour number the hospital has given you. It is often worse towards the end of treatment and for some weeks after it has finished. Isle of Man company number 4694F. Hearing changes usually get better after this treatment ends. They are named after the initials of the drugs used for treatment. XELOX and CAPOX are different names for the same combination of chemotherapy drugs. Chemotherapy forum requires membership for participation - click to join, Break in chemotherapy because of side effects. If you are worried about this, it is important to talk with your doctor before you start treatment. LOL. The main problems I've had was the Peripheral Neuropathy which started near the end of my treatment. Repeat every 21 days for 8 cycles for high-risk stage III colon cancer (any T4 and . For further information about this treatment go to the electronic Medicines Compendium (eMC)website. FOLFOX Protocol V1.2. Very rarely, this can cause heart failure or a heart attack. You may also find that some foods taste different from usual or that you prefer to eat spicier foods. Patients were randomly assigned (1:1) to chemotherapy every 3 weeks (intravenous oxaliplatin 130 mg/m 2 on day 1 plus either oral S-1 40 mg/m 2 [SOX] or oral capecitabine 1000 mg/m 2 [CAPOX], twice daily on days 1-14), in addition to either 360 mg nivolumab intravenously every 3 weeks (nivolumab plus chemotherapy group) or placebo (placebo plus chemotherapy group). Hi: I found out I had a tumor in my upper colon on February 7, 2017. Modifying the capecitabine dosing schedule from 14 days on, 7 days off (14/7) to 7 days on, 7 days off (7/7) may enable higher doses and improved antitumor efficacy in colorectal cancer xenografts. Some people may have side effects while they are being given the chemotherapy or shortly after they have it: Some people have an allergic reaction while having this treatment. This can be a: You mighthave treatmentthrough a thin short tube (a cannula) that goes into a vein in your arm. You may get some of the side effects we mention, but you are unlikely to get all of them. Feeling or being sickis usually well controlled with anti sickness medicines. avoid alcohol, tobacco, and foods that irritate your mouth and throat. Rarely some people might cough up blood or have unusual bleeding from the vagina. How often do you have oxaliplatin and capecitabine? Welcome. Aims: To determine the efficacy of the combination of oxaliplatin and capecitabine in patients with advanced colorectal cancer. Capecitabine is taken as tablets. Background: Oxaliplatin, combined with capecitabine (CAPOX) or infused 5-fluorouracil (FOLFOX), is standard of care in the adjuvant treatment of colorectal cancer (CRC). irinotecan single agent 2 weekly or 3 weekly protocol. ** Capecitabine is available as 150 mg and 500 mg tablets (refer to . Try to drink at least 2 litres (3 pints)of fluids each day. Vaccinations can reduce your risk of getting certain infections. These blood cells help the blood to clot when we cut ourselves. It may grow backa different colour or be curlier than before. Less common skin problems might include your skin getting dry, peeling, blistering, cracked, and changes in skin colour. Irinotecan & Capecitabine (14 day regimen) (I-Cap) Protocol V1.1. Registered office: 89 Albert Embankment, London SE1 7UQ. A reaction may happen during the infusion, causing a skin rash, itching, swelling of the lips, face or throat, breathing difficulties, fever and chills. Its a horrible condition . This treatment can reduce the number of white blood cells in your blood. Constipation is easier to sort out if you treat it early. These side effects happen in more than 10 in 100 people (more than 10%). You will be given XELOX in the chemotherapy day unit or during a stay in hospital. The virus is in the babys poo for about 2 weeks and could make you ill if your immunity is low. Take them in the morning after breakfast and then after your evening meal. If you do have a reaction, it can be treated quickly. Patients in both groups received adjuvant chemotherapy (capecitabine or fluorouracil and oxaliplatin) after CRT. Your doctor, nurse or pharmacist can tell you more about this. Bowel cancer means cancer that starts in the colon (large bowel) or back passage (rectum). Public Health England Although I mentioned it to the nurse who did my infusions I never mentioned it to the oncologist. The oncologist wasn't convinced the AF was caused by chemo so when I had lung mets surgically removed in 2016 he prescribedcapecitabine as a mop- up treatment. When the diarrhoea is better, they will tell you if you can start taking it again. Hair loss usually starts after your first or second treatment. Your nurse usually gives you anti-sickness (anti-emetic) drugs before the chemotherapy. Are you going to be on Avastin as well? Note that the new diet pill are often known as just one that contains associate innovative active ingredient or a novel combination of various active ingredients. Patients who were treated with both oxaliplatin and capecitabine had a higher risk of experiencing toxic side effects. Tell your doctor or nurse if you keep gettingheadaches. Before starting treatment with capecitabine you have a blood test to check levels of an enzyme called dihydropyrimidine dehydrogenase (DPD). Infections can sometimes be life threatening. wrap up warm and cover your nose and mouth in cold weather. your temperature goes below 36C (96.8F). sharp chest pain, which may be worse when you cough or take a deep breath. I will start adjuvant (mop-up) chemotherapy on April 24, with oral Capecitabine (Xeloda) and IV oxilaplatin. Rarely, these may be life-threatening. It is also known as colorectal cancer. 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